Does vitamin B6 help with fatigue during perimenopause?

Some women find that vitamin B6 helps manage fatigue during perimenopause, though individual results vary. The connection between vitamin B6 and fatigue involves how this supplement interacts with the hormonal and neurochemical pathways that become disrupted during perimenopause.

The evidence for using vitamin B6 specifically for fatigue ranges from anecdotal reports to clinical studies. What matters most is whether it works for your body. Many supplements need 4 to 8 weeks of consistent use before you can fairly evaluate their effect on symptoms like fatigue.

If you want to try vitamin B6 for fatigue: Start with a lower dose, choose a reputable brand with third-party testing, and track your fatigue severity daily so you have objective data. Continue your other management strategies (sleep, exercise, stress reduction) while testing vitamin B6 so you can isolate its effect.

Always check with your healthcare provider before starting vitamin B6, especially if you take other medications or have existing health conditions.