Is SAMe safe during perimenopause?

SAMe is generally considered safe for most women during perimenopause, though individual factors matter. As with any supplement, the quality of the product, the dosage, and your specific health situation all play a role.

Some women find SAMe helpful for managing perimenopause symptoms. However, supplements are not regulated as strictly as medications, so choosing a reputable brand with third-party testing is important.

Before starting SAMe, consider: Do you take any prescription medications that could interact? Do you have any liver, kidney, or hormonal conditions that might be affected? Have you discussed supplements with your healthcare provider?

Start with a lower dose and give it at least 4 to 8 weeks before evaluating results. Keep a symptom log so you can objectively assess whether SAMe is making a difference for you.